The U.S. Food and Drug Administration (FDA) prints warnings on the label and in the prescribing information for Prozac, stating that alcohol should never be mixed with the drug. Mayo Clinic reports that mixing alcohol and antidepressant medications can cause:

  • Increased sedation
  • Difficulties sleeping
  • Heightened levels of intoxication and impairment
  • Worsened symptoms of depression and anxiety
  • Potential problems with alcohol dependence

A staggering number of Americans take antidepressant medications, as many as 1 out of every 12 adults, the Centers for Disease Control and Prevention (CDC) reports. Prozac, or fluoxetine in its generic form, is a popular antidepressant medication prescribed to treat major depression, panic disorder, and obsessive-compulsive disorder (OCD), among other issues. Prozac is a selective serotonin reuptake inhibitor, or SSRI medication, that alters the brain’s chemistry by maintaining higher levels of serotonin, which is one of the naturally occurring, pleasure-inducing neurotransmitters. By stopping receptors from reabsorbing this neurotransmitter as quickly, more of these “happy cells” are present in the brain at one time, helping individuals to remain emotionally balanced and feel less depressed and anxious.

Alcohol can have similar effects as it also acts on some of the neurotransmitters responsible for feeling pleasure, increasing their levels in the brain as well. Alcohol may therefore be used as a form of self-medication for individuals who feel depressed and may seem to temporarily relieve symptoms of anxiety and depression. Regularly drinking alcohol as a method of coping with depressive symptoms, however, may increase the odds for developing a drinking problem that may manifest into addiction. Around 20 percent of Americans who suffer from a mood or anxiety disorder like depression also battle a substance use disorder involving alcohol or illicit drugs, and the reverse is also true, the Anxiety and Depression Association of America (ADAA) publishes.

Alcohol should never be mixed with an antidepressant medication like Prozac, as both substances may amplify the effects of the other, increasing the risk for overdose and other potentially dangerous side effects. Drinking alcohol while taking Prozac can also interfere with treatment for depression and/or anxiety.

Side Effects of Mixing Alcohol, Depression, and Prozac

alcohol and depression Alcohol may temporarily seem to elevate moods and decrease depressive symptoms; however, it can actually make these symptoms worse when it wears off. Depression can be amplified by the effects of alcohol, and Psych Central publishes that mixing alcohol with depression may actually increase a person’s risk for attempting or completing suicide.

Alcohol can lower a person’s inhibitions, impair judgment, and increase the odds for potentially violent or self-harming behaviors. When mixing alcohol with Prozac, it may not take as much alcohol to create a higher level of intoxication. Individuals may commit acts that are out of character for them and have no knowledge of doing so the next day.

The Pharmaceutical Journal reports that mixing an SSRI with alcohol can cause a higher level of impairment and exacerbated side effects than either substance alone may cause.

Alcohol is a central nervous system depressant, which lowers blood pressure, heart rate, body temperature, and breathing levels. Fluoxetine also interferes with some of these vital functions. If someone takes fluoxetine, they may suffer from an overdose, which may be indicated by an irregular heart rate, nausea, vomiting, drowsiness, tremors, and even seizures in some cases, the Western Journal of Emergency Medicine (WestJEM) reports. An overdose on alcohol is often called alcohol poisoning, and many of the same symptoms are observed. When these two substances are combined, the side effects are exaggerated, and an overdose may happen more quickly and at lower doses. Over 30 percent of the emergency department (ED) visits involving an antidepressant drug like Prozac in 2011 also involved alcohol, the Drug Abuse Warning Network (DAWN) reports.

Essentially, no one should ever combine Prozac and alcohol. If you are prescribed Prozac, discuss any other medications or substances you regularly consume with your doctor beforehand. If you abuse these substances by combining them, serious health effects can occur, and prompt treatment is needed.